O2P Oral Overdose Protection

In developing our SMART™ solutions, we ceased to fixate on “what is” and instead began to imagine “what if…?”

The Problem

In their current state, opioids are easy to abuse and overdose. The primary route of abuse is simply swallowing too many pills. Euphoria increases with the number of tablets consumed. This creates incentive to take more, which can lead to abuse and overdose. Additionally, the pain management effects of these opioids are short-acting, requiring more pills to be prescribed, resulting in ample opportunity for diversion, abuse and overdose.

What If…?

What if there was a smart opioid, that addressed the major risks of existing opioids without compromising their unmatched efficacy in treating pain patients?

Our SMART™ Solution

We have demonstrated human proof-of-concept that O2P delivers therapeutic hydrocodone at prescribed doses, and reduces exposure when supratherapeutic doses are swallowed. This safeguards against abuse and overdose. Further,  O2P provides a longer duration of action, reducing the number of tablets prescribed and, in turn, the risk of abuse, diversion, and overdose.

 

Core Benefits

  • Safeguards Against Abuse and Fatal Overdose

    “Self-limiting” opioid delivery means attenuated euphoric effects and protection against fatal overdose.

  • Limits Potential for Abuse

    Longer duration of action reduces the number of tablets prescribed; in turn, reducing the risk of abuse, diversion and fatal overdose which could reduce the next generation of opioid use disorder patients.

  • Retains Superior Efficacy of Opioids

    Provides patients with proven efficacy, while mitigating existing opioids major risks. Proper treatment of acute pain reduces morbidity, improves quality-of-life, facilitates recovery, reduces healthcare costs, and alleviates risk of developing chronic pain

  • Broadly Applicable to Opioids and Non-opioids

    O2P is broadly applicable to other medications that are a risk for misuse or overdose including oral opioids for pain and for Opioid Use Disorder (e.g., methadone).